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| Predictive value of Tp-Te interval on ventricular arrhythmias in patients with breast cancer treated by anthracycline-based chemotherapy |
| CHEN Xinyue, WANG Lujie, ZHAO Xili, DU Hairong, Abulimiti Zaimila,WANG Rui |
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Abstract Objective To explore the correlation between Tp-Te interval, Tp-Te / QT ratio and other ECG indexes, and the occurrence of ventricular arrhythmias in patients with breast cancer first treated by anthracycline based chemotherapy, and to investigate the predictive value of these ECG indexes. Methods A total of 150 females diagnosed with breast cancer were enrolled. All patients were treated by anthracycline chemotherapy. According to the occurrence of ventricular arrhythmias after treatment, these patients were divided into three groups: non-ventricular arrhythmia group ( n = 90 ), ventricular tachycardia group (n = 26) and premature ventricular contraction (PVC) group (n = 34). The general clinical data (including age, smoking history, diabetes history, hypertension history, Hb, TC, TG, HDL-C, LDL-C, K+, Na+and Ca2+), and ECG related indexes( including QT interval, Tp-Tec and Tp-Te / QT ) before and after treatment were compared among groups.Correlation analysis and receiver operating characteristic curve (ROC curve) were used to analyze the predictive value of ECG related indexes on the occurrence of ventricular tachycardia and PVC in patients with breast cancer after treatment. Results After treatment, the values of QTc, Tp-Tec and Tp-Te / QT in patients of the ventricular tachycardia group and the PVC group are all significantly increased (P<0. 05); these values are all higher than those in the normal controls(P<0. 05). Patients in the ventricular tachycardia group have the most obvious increase of ECG related indexes (P<0. 05). Spearman correlation analysis shows that QT interval, Tp-Tec and Tp-Te / QT are all significantly positively correlated with the occurrences of ventricular tachycardia and PVC in patients with breast cancer after treatment. ROC curve analysis indicates that the predictive value of Tp-Tec on the occurrences of ventricular tachycardia and PVC in patients with breast cancer is significantly higher than that of QTc and Tp-Te / QT; the best cut-off values are 93. 54 and 83. 07 ms, respectively. Conclusion QT interval, Tp-Te interval and Tp-Te / QT ratio have certain predictive value on the occurrence of ventricular arrhythmias in patients with breast cancer first treated by anthracycline-based chemotherapy, and the predictive value of Tp-Te interval is the highest. In the future, it may be used as an important ECG index to make early prediction and evaluation of the risk of ventricular arrhythmias in breast cancer patients undergoing chemotherapy, and provide theoretical basis for its early prevention and treatment.
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